Liver Injury and Immune Responses

The liver is a key, frontline immune tissue.  The balance between immunity and tolerance is important for the function of liver. Excessive inflammation in the absence of infection leads to sterile liver injury, tissue damage, and remodeling; insufficient immunity allows for chronic infection and cancer. Provocative phenotype can be credited to the intrinsic safe reaction produced by Kupffer cells, monocytes, neutrophils, and lymphocytes. The versatile invulnerable framework is affected by the intrinsic resistant reaction prompting liver harm.